CAL-130 Hydrochloride - CAS# 1431697-78-7 ifabutin Fenretinide inhibits OVCAR-5 cell proliferation

Fenretinide inhibits OVCAR-5 cell proliferation and viability at concentrations higher than 1 microM

Gardell SJ

CAS Number: 58-32-2

Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose

Polyamines are involved in nucleosome oligomerization and DNA conformation

CAL-130 Hydrochloride - CAS# 1431697-78-7 ifabutin Fenretinide inhibits OVCAR-5 cell proliferationCAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support